[Serotonin and hypothalamic control of hunger: a review]

Rev Assoc Med Bras (1992). 2011 Jan-Feb;57(1):74-7.
[Article in Portuguese]


This paper reviews involvement of the serotonergic system in the control of food intake and satiety. It is of great interest to understand the relevance of this system for physiological control of energy balance and obesity. Over 35 years of research suggest that serotonin (5-HT) plays an important role in satiety. Thus, the serotonergic system has been a viable target for weight control. The 5-HT has control over hunger and satiety through different receptors with distinct functions. The 5-HT2C receptor may be more important in the relationship between food intake and energy balance. This review will discuss the mechanisms of the serotonergic system involved in the control of food intake and satiety.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Eating / physiology*
  • Humans
  • Hunger / physiology*
  • Hypothalamus / metabolism*
  • Neurotransmitter Agents / physiology
  • Obesity / drug therapy
  • Satiation / drug effects
  • Satiation / physiology*
  • Serotonin / physiology
  • Serotonin 5-HT1 Receptor Agonists / physiology
  • Serotonin 5-HT2 Receptor Agonists / physiology
  • Serotonin Receptor Agonists / physiology*


  • Neurotransmitter Agents
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT2 Receptor Agonists
  • Serotonin Receptor Agonists
  • Serotonin