Papulonodular secondary syphilis in a 52-year-old non-HIV heterosexual patient

Acta Dermatovenerol Alp Pannonica Adriat. 2010 Dec;19(4):27-30.


There has been a recent increase in the incidence of syphilis in Slovenia, similar to other countries. Secondary syphilis can manifest with various clinical and histopathological presentations. We report the case of a 52-year-old patient that presented with nonpruritic nodular lesions on the face, trunk, and insteps that clinically mimicked lymphoma or sarcoidosis. Histopathological findings showed granulomatous inflammation. The serology revealed positive non-treponemal and treponemal tests. Treatment with benzathine penicillin G was successful.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Male
  • Middle Aged
  • Syphilis / diagnosis
  • Syphilis / drug therapy
  • Syphilis / pathology*
  • Syphilis Serodiagnosis
  • Syphilis, Cutaneous / diagnosis
  • Syphilis, Cutaneous / drug therapy
  • Syphilis, Cutaneous / pathology*

Supplementary concepts

  • Syphilis, secondary