Mycoestrogen pollution of Italian infant food

J Pediatr. 2011 Aug;159(2):278-83.e1. doi: 10.1016/j.jpeds.2011.01.028. Epub 2011 Mar 10.

Abstract

Objective: To determine the concentrations of zearalenone and its metabolites in the leading brands of infant formula milks and meat-based infant foods commonly marketed in Italy, and to assess their repercussion in the provisional tolerable daily intakes of these estrogenic mycotoxins.

Study design: A total of 185 cow's milk-based infant formulas and 44 samples of meat-based infant foods samples were analyzed. The analysis of mycotoxins was performed by immunoaffinity column clean-up and high-pressure liquid chromatography with fluorescence detection.

Results: Zearalenone was detected in 17 (9%) milk samples (maximum 0.76 μg/L). The α-zearalenol was detected in 49 (26%) milk samples (maximum 12.91 μg/L). The β-zearalenol was detected in 53 (28%) milk samples (maximum 73.24 μg/L). The α-zearalanol and β-zearalanol were not detected in milk samples. Although α-zearalenol was detected in 12 (27%) meat samples (maximum 30.50 μg/kg), only one meat-based sample was contaminated by α-zearalanol (950 μg/kg). Zearalenone, β-zearalenol, and β-zearalanol were not detected in meat samples.

Conclusions: This study shows the presence of mycoestrogens in infant (milk-based and meat-based) food, and this is likely to have great implications for subsequent generations, suggesting the need to perform occurrence surveys in this type of food.

MeSH terms

  • Animals
  • Chromatography, High Pressure Liquid
  • Food Contamination / analysis*
  • Foodborne Diseases / epidemiology
  • Foodborne Diseases / etiology
  • Humans
  • Incidence
  • Infant
  • Infant Food / analysis*
  • Infant Food / poisoning
  • Infant Formula / chemistry*
  • Infant, Newborn
  • Italy / epidemiology
  • Meat / analysis*
  • Meat / poisoning
  • Milk / chemistry*
  • Milk / poisoning
  • Retrospective Studies
  • Zearalenone / analysis*
  • Zearalenone / poisoning

Substances

  • Zearalenone