TREM-1 interaction with the LPS/TLR4 receptor complex

Eur Cytokine Netw. 2011 Mar;22(1):11-4. doi: 10.1684/ecn.2011.0274.


Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor expressed on neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors. In this study, several lines of evidence are presented that TREM-1 interacts with the toll-like receptor 4 (TLR4) receptor complex, or is a component of this complex. Blocking anti-TREM-1 antibodies specifically inhibited LPS-induced TNF-α production, while the alternative approach of blocking TLR4 by a specific inhibitor led to a down-regulation of the effects of TREM-1 cross-linking. These data are in line with the TLR4-TREM1 co-localization in human neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with the TLR4/LPS-receptor complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Lipopolysaccharides / metabolism*
  • Lipopolysaccharides / pharmacology
  • Membrane Glycoproteins / metabolism*
  • Protein Binding / drug effects
  • Receptors, Immunologic / metabolism*
  • Toll-Like Receptor 4 / metabolism*
  • Triggering Receptor Expressed on Myeloid Cells-1


  • Lipopolysaccharides
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • TLR4 protein, human
  • TREM1 protein, human
  • Toll-Like Receptor 4
  • Triggering Receptor Expressed on Myeloid Cells-1