Sudden, unexpected and natural death in young adults of age between 18 and 35 years: a clinicopathological study

Indian J Pathol Microbiol. 2011 Jan-Mar;54(1):47-50. doi: 10.4103/0377-4929.77323.


Context: To identify various causes, risk factors, age and sex distribution associated with sudden and unexpected natural deaths (SUNDs) in young adults of age between 18 and 35 years.

Materials and methods: Retrospective analysis of autopsy reports and medical records of all SUNDs that occurred instantaneously or within 24 hours of onset of symptoms in young adults, between 2001 and 2009.

Result: Of the total 6453 deaths autopsied during 2001-2009, 64 (0.99%) were SUNDs in young adults, chiefly in males between 30 and 35 years of age. Non-cardiac causes significantly predominated (73.4%) over cardiac causes (7.8%). Most of the SUND cases were due to preventable causes, including infections (54.6% cases), cerebrovascular accidents (9.37%) and ischemic cardiac causes (6.25%). Sudden adult death syndrome (SADS) accounted for 18.75% deaths.

Conclusion: SUND in young adults is preventable. A meticulous post-mortem examination with special attention to the conduction system of heart and detailed toxicological analysis can pinpoint the cause of death in SADS.

MeSH terms

  • Adolescent
  • Adult
  • Autopsy
  • Communicable Diseases / mortality
  • Death, Sudden / epidemiology*
  • Death, Sudden / etiology*
  • Female
  • Humans
  • Male
  • Myocardial Ischemia / mortality
  • Prevalence
  • Retrospective Studies
  • Stroke / mortality
  • Young Adult