[Influence of metformin and N-acetylcysteine on hormonal and genotoxic effects of estrogens and glucose in convalescent cancer patients]

Vopr Onkol. 2010;56(6):664-70.
[Article in Russian]

Abstract

Our study involved 25 postmenopausal patients (endometrial carcinoma--16, breast (6) and colorectal (3) cancer, aged 56.8 +/- 0.9). All patients were in clinical remission. None had received any specific therapy for at least 12 months. After a laboratory endocrine-genotoxic switch evaluation, 17 patients were given an antidiabetic drug--biguanide metformin--or N-acetylcysteine as antioxidant (8) for 3 months. A checkup was carried out on completion of the course. As a result, hormonal and progenotoxic effects of glucose were found to be inhibited significantly. Much less pronounced was the impact on relevant effects of estradiol which were investigated vis-a-vis nature of blood mononuclear response in vitro. Both isolated and combined administration of said drugs used for endocrine-metabolic rehabilitation is justified.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Acetylcysteine / administration & dosage
  • Acetylcysteine / pharmacology
  • Acetylcysteine / therapeutic use*
  • Aged
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism
  • Body Mass Index
  • Breast Neoplasms / metabolism
  • Colonic Neoplasms / metabolism
  • Drug Administration Schedule
  • Endometrial Neoplasms / metabolism
  • Estrogens / metabolism*
  • Female
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology
  • Free Radical Scavengers / therapeutic use*
  • Glucose / metabolism*
  • Humans
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / pharmacology
  • Hypoglycemic Agents / therapeutic use*
  • Interleukin-6 / blood
  • Metformin / administration & dosage
  • Metformin / pharmacology
  • Metformin / therapeutic use*
  • Middle Aged
  • Neoplasms / blood
  • Neoplasms / metabolism*
  • Postmenopause
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Blood Glucose
  • Estrogens
  • Free Radical Scavengers
  • Hypoglycemic Agents
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • Metformin
  • Glucose
  • Acetylcysteine