Use and implications of the harmonic mean model on mixtures for basic research and drug discovery

ACS Comb Sci. 2011 May 9;13(3):337-44. doi: 10.1021/co100065a. Epub 2011 Mar 11.


The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complex Mixtures*
  • Drug Discovery*
  • Models, Chemical*


  • Complex Mixtures