Visualization and genetic manipulation of adult neurogenesis using transgenic mice

Eur J Neurosci. 2011 Mar;33(6):1025-36. doi: 10.1111/j.1460-9568.2011.07600.x.


Many laboratories have focused efforts on the creation of transgenic mouse models to study adult neurogenesis. In the last decade several constitutive reporter, as well as inducible transgenic lines have been published that allowed for visualization, tracking and alteration of specific neurogenic cell populations in the adult brain. Given the popularity of this approach, multiple mouse lines are available, and this review summarizes the differences in the basic techniques that have been used to create these mice, highlighting the different constructs and reporter proteins used, as well as the strengths and limitations of each of these models. Representative examples from the literature demonstrate some of the diverse and seminal findings that have come to fruition through the laborious, yet highly rewarding work of creating transgenic mouse lines for adult neurogenesis research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / cytology
  • Adult Stem Cells / physiology*
  • Animals
  • Genes, Reporter
  • Humans
  • Mice
  • Mice, Transgenic*
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neurogenesis / physiology*


  • Nerve Tissue Proteins