Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation

Pediatr Transplant. 2012 Aug;16(5):E146-9. doi: 10.1111/j.1399-3046.2011.01487.x. Epub 2011 Mar 13.


PAP is a rare alveolointerstitial lung disorder characterized histologically by the intra-alveolar accumulation of eosinophilic and PAS-positive material. We observed two cases of PAP after unrelated CB hematopoietic progenitor cell transplantation in children with ALL. No antagonist activity toward GM-CSF was identified in the patient tested. The putative multifactorial PAP etiology is discussed. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Child, Preschool
  • Cord Blood Stem Cell Transplantation*
  • Fatal Outcome
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery*
  • Pulmonary Alveolar Proteinosis / diagnosis*
  • Pulmonary Alveolar Proteinosis / etiology