The role of LKB1 and AMPK in cellular responses to stress and damage

FEBS Lett. 2011 Apr 6;585(7):952-7. doi: 10.1016/j.febslet.2011.03.010. Epub 2011 Mar 12.


The LKB1 and AMPK proteins participate in an energy sensing cascade that responds to depletion of ATP, serving as a master regulator of metabolism that inhibits anabolic processes and stimulates catabolic processes. However in recent years, LKB1 and AMPK have been implicated in a variety of other cellular processes, both cytoplasmic and nuclear, such as control of cell polarity and regulation of gene transcription. In this review, we summarize the most recent discoveries regarding participation of LKB1 and AMPK in signaling pathways that respond to cellular stress and damage, and the relevance of this signaling for disease and therapy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • AMP-Activated Protein Kinase Kinases
  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Cell Death
  • Cells / enzymology*
  • Cells / metabolism
  • Cells / pathology*
  • Humans
  • Organ Specificity
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction


  • Protein Serine-Threonine Kinases
  • STK11 protein, human
  • AMP-Activated Protein Kinase Kinases
  • AMP-Activated Protein Kinases