Differences in Quantitative EEG Between Frontotemporal Dementia and Alzheimer's Disease as Revealed by LORETA

Clin Neurophysiol. 2011 Sep;122(9):1718-25. doi: 10.1016/j.clinph.2011.02.011. Epub 2011 Mar 10.


Objective: To determine the electrophysiological characteristics of frontotemporal dementia (FTD) and the distinction with Alzheimer's disease (AD).

Methods: We performed analyses of global field power (GFP) which is a measure of whole brain electric field strength, and EEG neuroimaging analyses with sLORETA (standardized low resolution electromagnetic tomography), in the mild stages of FTD (n = 19; mean age = 68.11 ± 7.77) and AD (n = 19; mean age = 69.42 ± 9.57) patients, and normal control (NC) subjects (n = 22; mean age = 66.13 ± 6.02).

Results: In the GFP analysis, significant group effects were observed in the delta (1.5-6.0 Hz), alpha1 (8.5-10.0 Hz), and beta1 (12.5-18.0 Hz) bands. In sLORETA analysis, differences in activity were observed in the alpha1 band (NC > FTD) in the orbital frontal and temporal lobe, in the delta band (AD>NC) in widespread areas including the frontal lobe, and in the beta1 band (FTD > AD) in the parietal lobe and sensorimotor area.

Conclusions: Differential patterns of brain regions and EEG frequency bands were observed between the FTD and AD groups in terms of pathological activity.

Significance: FTD and AD patients in the early stages displayed different patterns in the cortical localization of oscillatory activity across different frequency bands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / diagnosis*
  • Alzheimer Disease / physiopathology*
  • Electroencephalography
  • Female
  • Frontotemporal Dementia / diagnosis*
  • Frontotemporal Dementia / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Signal Processing, Computer-Assisted*