Abstract
Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Amyloid / metabolism*
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Caspases / metabolism
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Chromosomal Proteins, Non-Histone / metabolism
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DNA-Binding Proteins / metabolism
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Epigenomics
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Glutathione Peroxidase / metabolism
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Peptide Termination Factors / metabolism
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Prions / chemistry*
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Prions / metabolism*
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Proton-Translocating ATPases / metabolism
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Repressor Proteins / metabolism
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Saccharomyces cerevisiae Proteins / chemistry*
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Saccharomyces cerevisiae Proteins / metabolism*
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Saccharomycetales / metabolism*
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Transcription Factors / metabolism
Substances
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Amyloid
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CYC8 protein, S cerevisiae
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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MOT3 protein, S cerevisiae
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Peptide Termination Factors
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Prions
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RNQ1 protein, S cerevisiae
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Repressor Proteins
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SFP1 protein, S cerevisiae
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SUP35 protein, S cerevisiae
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SWI1 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Glutathione Peroxidase
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URE2 protein, S cerevisiae
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Caspases
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MCA1 protein, S cerevisiae
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PMA1 protein, S cerevisiae
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Proton-Translocating ATPases