C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain

Biochem Biophys Res Commun. 1990 Apr 30;168(2):863-70. doi: 10.1016/0006-291x(90)92401-k.


Two types of natriuretic peptide, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), very similar to each other in structure and in pharmacological effect, are known to be present in mammalian heart and brain. In our present survey for unidentified peptides in porcine brain extracts, we found a new peptide of 22 amino acid residues, eliciting a potent relaxant activity on chick rectum. The amino acid sequence determined for the peptide shows remarkable similarity to those of ANP and BNP, especially in the 17-residue sequences flanked by two cysteine residues. The peptide shows a pharmacological spectrum similar to ANP and BNP. Thus, the peptide was designated "C-type natriuretic peptide (CNP)", the third member to join the natriuretic peptide family. In contrast to ANP and BNP, CNP terminates in the second cysteine residue, lacking a further C-terminal extension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Atrial Natriuretic Factor / analysis*
  • Brain Chemistry*
  • Chickens
  • Molecular Sequence Data
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Nerve Tissue Proteins / analysis*
  • Protein Conformation
  • Rectum / metabolism
  • Swine


  • Nerve Tissue Proteins
  • Natriuretic Peptide, Brain
  • Natriuretic Peptide, C-Type
  • Atrial Natriuretic Factor