Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1

Lance S Terada; Fiemu E Nwariaku

doi:10.1016/j.ccr.2011.02.019

Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1

Cancer Cell. 2011 Mar 8;19(3):297-9. doi: 10.1016/j.ccr.2011.02.019.

Authors

Lance S Terada¹, Fiemu E Nwariaku

Affiliation

¹ Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

PMID: 21397852
DOI: 10.1016/j.ccr.2011.02.019

Abstract

Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.

Publication types

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MeSH terms

Angiopoietin-Like Protein 4
Angiopoietins / genetics
Angiopoietins / metabolism*
Animals
Anoikis*
Cell Line, Tumor
Humans
Hydrogen Peroxide / metabolism*
Integrins / metabolism
Mice
Mice, Knockout
NADPH Oxidase 1
NADPH Oxidases / metabolism
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / pathology
Protein Binding
Signal Transduction
Superoxides / metabolism*

Substances

ANGPTL4 protein, human
Angiopoietin-Like Protein 4
Angiopoietins
Integrins
Superoxides
Hydrogen Peroxide
NADPH Oxidase 1
NADPH Oxidases
NOX1 protein, human