Escaping Anoikis through ROS: ANGPTL4 controls integrin signaling through Nox1

Cancer Cell. 2011 Mar 8;19(3):297-9. doi: 10.1016/j.ccr.2011.02.019.

Abstract

Reactive oxygen species (ROS) mediate various cell fate decisions in normal and transformed cells. In this issue of Cancer Cell, Zhu et al. demonstrate the ability of ANGPTL4 to engage integrin-dependent survival signals by activation of the NADPH oxidase Nox1, thus mimicking anchorage conditions and bypassing anoikis by controlling ROS.

Publication types

  • Comment

MeSH terms

  • Angiopoietin-like 4 Protein
  • Angiopoietins / genetics
  • Angiopoietins / metabolism*
  • Animals
  • Anoikis*
  • Cell Line, Tumor
  • Humans
  • Hydrogen Peroxide / metabolism*
  • Integrins / metabolism
  • Mice
  • Mice, Knockout
  • NADPH Oxidase 1
  • NADPH Oxidases / metabolism
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Protein Binding
  • Signal Transduction
  • Superoxides / metabolism*

Substances

  • ANGPTL4 protein, human
  • Angiopoietin-like 4 Protein
  • Angiopoietins
  • Integrins
  • Superoxides
  • Hydrogen Peroxide
  • NADPH Oxidase 1
  • NADPH Oxidases
  • NOX1 protein, human