Erratum To: Resveratrol and Red Wine, Healthy Heart and Longevity

Heart Fail Rev. 2011 Jul;16(4):425-35. doi: 10.1007/s10741-011-9234-6.

Abstract

Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Review
  • Corrected and Republished Article

MeSH terms

  • Aging / drug effects
  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Cardiotonic Agents / chemistry
  • Cardiotonic Agents / pharmacology*
  • Health Status*
  • Heart / drug effects*
  • Humans
  • Longevity / drug effects
  • Resveratrol
  • Stilbenes / chemistry
  • Stilbenes / pharmacology*
  • Wine*

Substances

  • Antioxidants
  • Cardiotonic Agents
  • Stilbenes
  • Resveratrol