Calorie restriction and prevention of age-associated chronic disease

FEBS Lett. 2011 Jun 6;585(11):1537-42. doi: 10.1016/j.febslet.2011.03.015. Epub 2011 Mar 12.


Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and human primates, CR with adequate nutrition protects against abdominal obesity, diabetes, hypertension and cardiovascular diseases. Cancer morbidity and mortality are also diminished in CR monkeys, and data obtained from individuals practicing long-term CR show a reduction of metabolic and hormonal factors associated with increased cancer risk.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging* / metabolism
  • Animals
  • Caloric Restriction*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / prevention & control
  • Chronic Disease / prevention & control*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / prevention & control