Surgical treatment of hypopharyngeal cancer is indicated in advanced stages and recurrent/persistent disease after conservative regimens. As of today, no criterion standard treatment is applicable to all cases. Comparing functional results, complication rates and feasibility of different techniques proposed (free flaps, gastric pull-up, etc), and poor outcome in disease-free survival and in overall survival are more related to the tumor stage rather than the reconstruction technique. The authors discuss reconstructive surgery performed in 52 patients using a pectoralis major myocutaneous flap, according to a technique proposed by Spriano et al in 2001, after total circular partial/total hypopharyngectomy and total laryngectomy from January 1993 to 2008. Primary surgical treatment was performed in 38 patients. Surgery after radiotherapy/chemotherapy failure was performed in 8 patients. Surgery after chemotherapy was performed in 6 patients. Postoperative radiation treatment was administered in 35 patients. Two patients did not receive complementary radiotherapy: 1 patient died perioperatively and 1 had previous radiation treatment in 2002 for oropharyngeal cancer. Follow-up period ranged from a minimum of 7 months to a maximum of 15 years. Overall survival was 19.6%. To date, disease-free survival is 9 (17.3%) of 52 patients. Long-term follow-up shows that late complications are low or absent. For this reason, we consider this procedure to be time-sparing and safe, especially in this category of patients commonly affected by malnutrition and other long-term diseases.