Value of distal compound muscle action potential duration prolongation in acute inflammatory demyelinating polyneuropathy: a European perspective

Muscle Nerve. 2011 May;43(5):751-5. doi: 10.1002/mus.21974. Epub 2011 Mar 14.


Introduction: The value of distal compound muscle action potential duration (DCMAPD) has not been widely studied in acute inflammatory demyelinating polyneuropathy (AIDP) with electromyography (EMG) equipment at low-cut filter settings <10 Hz, as used in Europe.

Methods: We retrospectively reviewed the records of 40 patients with AIDP and 40 controls with axonal neuropathy, from Leicester, UK, and Angers, France.

Results: The best combination of sensitivity/specificity for AIDP using DCMAPD prolongation in any one nerve was offered by cut-offs from two other studies (sensitivity: 90% and 87.5%, respectively; specificity: 92.5% for both). Independent DCMAPD prolongation in any one nerve was better than, or equivalent to, other criteria.

Conclusions: DCMAPD prolongation in any one nerve, at cut-offs suggested by prior studies, represents a sensitive and specific marker to aid/simplify electrodiagnosis of AIDP in patients studied with EMG equipment with low-cut filter settings of <10 Hz.

Publication types

  • Comparative Study

MeSH terms

  • Action Potentials / physiology*
  • Electromyography / methods
  • Europe / epidemiology
  • Female
  • Guillain-Barre Syndrome / epidemiology*
  • Guillain-Barre Syndrome / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / physiopathology*
  • Retrospective Studies
  • Time Factors