Current status and new developments in Peyronie's disease: medical, minimally invasive and surgical treatment options

Expert Opin Pharmacother. 2011 Apr;12(6):931-44. doi: 10.1517/14656566.2011.544252.


Introduction: Peyronie's disease (PD) is a wound-healing disorder of the tunica albuginea of the penis which affects 3-9% of adult males. Clinically, any combination of plaque formation, penile pain, angulation and erectile dysfunction may appear. This condition may progress, stabilize or, uncommonly, regress during the initial acute phase (6-18 months).

Areas covered: Information regarding this review was searched in PubMed until August 2010. Vitamin E, paraaminobenzoate and colchicine are sparingly employed oral medical therapies. Intralesional injections as a minimally invasive therapy for PD includes injection with verapamil, interferon-α-2b, and collagenase. Men suffering with PD who have significant penile deformity precluding successful coitus can be appraised for surgical correction. Surgery is considered the gold standard and includes plication, incision and grafting- or penile-prosthesis-related procedures.

Expert opinion: This paper provides a broad overview of the subject of PD, available nonsurgical options and surgical approaches that will aid in the routine clinical diagnosis and management of PD. Increased public and medical awareness of PD prevalence, presentation, diagnosis and treatment options will serve well the large population of men who suffer in silence with this common condition.

Publication types

  • Review

MeSH terms

  • 4-Aminobenzoic Acid / therapeutic use
  • Colchicine / therapeutic use
  • Collagenases / administration & dosage
  • Drug Administration Routes
  • Humans
  • Interferon-alpha / administration & dosage
  • Male
  • Minimally Invasive Surgical Procedures*
  • Penile Implantation
  • Penile Induration / etiology
  • Penile Induration / therapy*
  • Penis / pathology
  • Penis / physiopathology
  • Penis / surgery
  • Pharmaceutical Preparations / administration & dosage*
  • PubMed
  • Radiotherapy
  • Verapamil / administration & dosage
  • Vitamin E / therapeutic use


  • Interferon-alpha
  • Pharmaceutical Preparations
  • Vitamin E
  • Verapamil
  • Collagenases
  • Colchicine
  • 4-Aminobenzoic Acid