Pentagone: patrolling BMP morphogen signaling

Fly (Austin). Jul-Sep 2011;5(3):210-4. doi: 10.4161/fly.5.3.15311. Epub 2011 Jul 1.


Orchestration of spatial organization by signaling gradients--morphogen gradients--is a fundamental principle in animal development. Despite their importance in tissue patterning and growth, the exact mechanisms underlying the establishment and maintenance of morphogen gradients are poorly understood. Our recent work on BMP (bone morphogenetic protein) morphogen signaling during wing development identified a novel protein, Pentagone (Pent), as a critical regulator of morphogen activity. In the following, we discuss the properties of Pent and its role as a feed-back loop in morphogen gradient formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / metabolism*
  • Extracellular Matrix Proteins / metabolism*
  • Feedback, Physiological


  • Bone Morphogenetic Proteins
  • Drosophila Proteins
  • Extracellular Matrix Proteins
  • Magu protein, Drosophila
  • dpp protein, Drosophila