The Iowa multiplex family study of schizophrenia: linkage analyses on chromosome 5

Eur Arch Psychiatry Neurol Sci. 1990;239(5):290-2. doi: 10.1007/BF01735053.


We analysed six multiplex pedigrees of schizophrenia for linkage to two DNA probes mapping to the chromosome 5q11-q13 region where linkage to a gene for schizophrenia was recently reported. Analyses were conducted using three penetrance models and considering the affected state to be schizophrenia, the schizophrenia spectrum, and all psychiatric diagnoses. All analyses gave consistently negative lod scores. Although the region was not formally excluded, no evidence for linkage was found.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 5*
  • DNA Probes
  • Depressive Disorder / genetics
  • Genetic Linkage / genetics*
  • Genetic Markers
  • Humans
  • Iowa
  • Models, Genetic
  • Psychotic Disorders / genetics
  • Schizophrenia / genetics*
  • Schizotypal Personality Disorder / genetics


  • DNA Probes
  • Genetic Markers