Effect of Decapeptyl, an agonistic analog of gonadotropin-releasing hormone on estrogens, estrogen sulfates, and progesterone receptors in leiomyoma and myometrium

Fertil Steril. 1990 Jun;53(6):1012-7.

Abstract

Estrogens (estrone [E1] and estradiol [E2]), their sulfates and progesterone receptor (PR) were evaluated in patients with uterine leiomyomata nontreated and treated with Decapeptyl (D-Trp6-gonadotropin-releasing hormone [GnRH]; Ipsen Biotech, Paris, France). Estrogen concentrations are very high in the leiomyoma (secretory phase, pg/g tissue [mean +/- SEM]: n = 10; E1: 147 +/- 24; E2: 850 +/- 116; E1-sulfate: 1,668 +/- 808; E2-sulfate: 718 +/- 126). Decapeptyl treatment provokes a significant decrease in E2 and particularly in E1 and E2 sulfates. Progesterone receptors were higher in the leiomyoma than in the myometrium; after a long treatment (3 to 4 months) a significant decrease in both tissues is observed. The decrease provoked by D-Trp6-GnRH on estrogens (unconjugated and sulfates) and in PR in the leiomyoma after long treatment, supports the hypothesis that estrogens are implicated in the cause of these tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antineoplastic Agents / pharmacology*
  • Estradiol / analogs & derivatives
  • Estradiol / metabolism
  • Estrogens / metabolism*
  • Estrone / analogs & derivatives
  • Estrone / metabolism
  • Female
  • Gonadotropin-Releasing Hormone / analogs & derivatives*
  • Gonadotropin-Releasing Hormone / pharmacology
  • Humans
  • Leiomyoma / drug therapy*
  • Middle Aged
  • Myometrium / drug effects*
  • Myometrium / metabolism
  • Receptors, Progesterone / metabolism*
  • Triptorelin Pamoate
  • Uterine Neoplasms / drug therapy*
  • Uterine Neoplasms / metabolism

Substances

  • Antineoplastic Agents
  • Estrogens
  • Receptors, Progesterone
  • Triptorelin Pamoate
  • estradiol sulfate
  • Estrone
  • Gonadotropin-Releasing Hormone
  • Estradiol
  • estrone sulfate