Repeatability of optic nerve head parameters measured by spectral-domain OCT in healthy eyes

Ophthalmic Surg Lasers Imaging. 2011 May-Jun;42(3):209-15. doi: 10.3928/15428877-20110224-02. Epub 2011 Mar 3.


Background and objective: To evaluate the repeatability of optic nerve head (ONH) measurements by spectral-domain optical coherence tomography.

Patients and methods: Three scans were acquired in 32 healthy subjects during one session. Using Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), the cup-to-disc ratio (CDR), disc area, rim area, cup volume, and horizontal and vertical CDRs were investigated. Repeatability was assessed by the coefficient of variation (COV), the test-retest intrasession variability, and the intraclass correlation coefficient (ICC).

Results: Good repeatability was achieved for all parameters, with a COV of 4.23% or less and ICCs of 0.98 or greater for all measurements. Test-retest intrasession variability was 0.024 for CDR, 0.121 mm(2) for disc area, 0.087 mm(2) for rim area, 0.017 mm(3) for cup volume, and 0.048 for horizontal and vertical CDR.

Conclusion: In healthy eyes, Cirrus HD-OCT provides repeatable measurements of ONH parameters.

MeSH terms

  • Humans
  • Middle Aged
  • Optic Disk / anatomy & histology*
  • Prospective Studies
  • Reference Values
  • Reproducibility of Results
  • Tomography, Optical Coherence / instrumentation*