Cilofungin inhibition of (1-3)-beta-glucan synthase: the lipophilic side chain is essential for inhibition of enzyme activity

J Antibiot (Tokyo). 1990 Apr;43(4):433-7. doi: 10.7164/antibiotics.43.433.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents*
  • Antifungal Agents / pharmacology*
  • Candida albicans / enzymology*
  • Echinocandins
  • Fungal Proteins*
  • Glucosyltransferases / antagonists & inhibitors*
  • Membrane Proteins*
  • Molecular Structure
  • Neurospora / enzymology*
  • Neurospora crassa / enzymology*
  • Peptides / pharmacology
  • Peptides, Cyclic*
  • Schizosaccharomyces pombe Proteins*
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Echinocandins
  • Fungal Proteins
  • Membrane Proteins
  • Peptides
  • Peptides, Cyclic
  • Schizosaccharomyces pombe Proteins
  • aculeacin A
  • cilofungin
  • echinocandin B
  • Glucosyltransferases
  • 1,3-beta-glucan synthase