Transfer of KPC-2 Carbapenemase from Klebsiella pneumoniae to Escherichia coli in a patient: first case in Europe

J Clin Microbiol. 2011 May;49(5):2040-2. doi: 10.1128/JCM.00133-11. Epub 2011 Mar 16.

Abstract

The first case in Europe of Klebsiella pneumoniae carbapenemase (KPC) 2 transfer from K. pneumoniae to Escherichia coli in the same patient is described. KPC-positive plasmids from the two species were identical, indicating horizontal plasmid transfer. Selection of the KPC-producing E. coli strain was triggered by therapy with meropenem.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics*
  • Europe
  • Gene Transfer, Horizontal*
  • Humans
  • Klebsiella pneumoniae / enzymology
  • Klebsiella pneumoniae / genetics
  • Male
  • Meropenem
  • Middle Aged
  • Plasmids / analysis
  • Selection, Genetic
  • Thienamycins / therapeutic use
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • beta-lactamase KPC-2
  • beta-Lactamases
  • Meropenem