Successful memory response following a booster dose with a virosome-formulated hepatitis a vaccine delayed up to 11 years

Christoph Hatz; Robert van der Ploeg; Bernhard R Beck; Gert Frösner; Marjory Hunt; Christian Herzog

doi:10.1128/CVI.00358-10

Successful memory response following a booster dose with a virosome-formulated hepatitis a vaccine delayed up to 11 years

Clin Vaccine Immunol. 2011 May;18(5):885-7. doi: 10.1128/CVI.00358-10. Epub 2011 Mar 16.

Authors

Christoph Hatz¹, Robert van der Ploeg, Bernhard R Beck, Gert Frösner, Marjory Hunt, Christian Herzog

Affiliation

¹ Medical Department Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland. christoph.hatz@unibas.ch

Abstract

Boosting adult travelers with the virosome-formulated, aluminum-free hepatitis A vaccine Epaxal up to 128 months after a single primary dose confers full protection against hepatitis A, even in travelers aged 50 years and above. Delaying the booster dose did not influence the immune memory response to Epaxal.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Female
Hepatitis A / immunology
Hepatitis A / prevention & control*
Hepatitis A Vaccines / administration & dosage*
Hepatitis A Vaccines / immunology*
Humans
Immunization, Secondary / methods*
Immunologic Memory*
Male
Middle Aged
Time Factors
Vaccines, Virosome / administration & dosage
Vaccines, Virosome / immunology

Substances

Hepatitis A Vaccines
Vaccines, Virosome
epaxal berna