Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 May;89(5):662-73.
doi: 10.1038/clpt.2011.34. Epub 2011 Mar 16.

Pharmacogenetics: From Bench to Byte--An Update of Guidelines

Affiliations
Review

Pharmacogenetics: From Bench to Byte--An Update of Guidelines

J J Swen et al. Clin Pharmacol Ther. .

Abstract

Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch Association for the Advancement of Pharmacy established the Pharmacogenetics Working Group with the objective of developing pharmacogenetics-based therapeutic (dose) recommendations. After systematic review of the literature, recommendations were developed for 53 drugs associated with genes coding for CYP2D6, CYP2C19, CYP2C9, thiopurine-S-methyltransferase (TPMT), dihydropyrimidine dehydrogenase (DPD), vitamin K epoxide reductase (VKORC1), uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1), HLA-B44, HLA-B*5701, CYP3A5, and factor V Leiden (FVL).

Similar articles

See all similar articles

Cited by 237 articles

See all "Cited by" articles

MeSH terms

Substances

LinkOut - more resources

Feedback