The evaluation of quality of life (QOL) faced with chronic ischemic pain involves the clients in their subjectivity and multidimensionality. This descriptive study aimed to evaluate the quality of life of clients who presented chronic ischemic pain. A total of 100 clients of hospital institutes participated in the study. The instrument used to assess pain was an 11 point numerical scale, and to assess the quality of life, the World Health Organization Quality of Life-abbreviated questionnaire. The arithmetic mean for chronic pain was 5.59 ± 3.16 points. The means for quality of life were: in the physical domain, 44.75 ± 16.98; in the overall domain, 50.0 ± 22.40; in the environment, 55.06 ± 13.51, in the psychological, 56.21 ± 17.19 and in the social domain, 68.33 ± 21.84. Thus, the physical domain was, among the areas analyzed, the one which presented a greater impact on the quality of life of the clients with chronic ischemic pain.