Ventricular enlargement and mild cognitive impairment in early Parkinson's disease

Mov Disord. 2011 Feb 1;26(2):297-301. doi: 10.1002/mds.23443. Epub 2010 Dec 13.


Mild cognitive impairment (MCI) may predict future development of dementia in Parkinson's disease (PD). We aimed to examine the extent of subcortical brain atrophy in patients with early PD with and without MCI compared to normal controls (NC). Participating in a population-based study were 43 early, drug-naïve PD patients and 41 NC. Eleven patients were classified with MCI (MCI PD) and 32 patients without (non-MCI PD). Volumetric segmentation of 3D-T1 weighted brain MRI was performed using FreeSurfer. Groups were compared applying MANCOVA corrected for total intracranial volume, age, and sex. Results showed that left inferior lateral ventricle and third ventricle volumes were significantly larger in MCI PD than in non-MCI PD and NC. Fourth ventricular size in MCI PD was significantly different from NC and highly correlated with memory performance in MCI PD patients. This suggests that cognitive dysfunction in early PD may be associated with ventricular enlargement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Analysis of Variance
  • Cognition Disorders / pathology*
  • Cognition Disorders / physiopathology
  • Disease Progression
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Lateral Ventricles / pathology*
  • Lateral Ventricles / physiopathology
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Parkinson Disease / pathology*
  • Parkinson Disease / physiopathology
  • Severity of Illness Index
  • Third Ventricle / pathology*
  • Third Ventricle / physiopathology