Hybrid lipoic acid derivatives to attack prion disease on multiple fronts

ChemMedChem. 2011 Apr 4;6(4):601-5. doi: 10.1002/cmdc.201100072. Epub 2011 Mar 15.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Cell Line
  • Cell Survival / drug effects
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use*
  • PrPSc Proteins / metabolism
  • Prion Diseases / drug therapy*
  • Prion Diseases / metabolism
  • Prion Diseases / pathology
  • Scrapie / metabolism
  • Scrapie / pathology
  • Structure-Activity Relationship
  • Thioctic Acid / analogs & derivatives
  • Thioctic Acid / chemical synthesis
  • Thioctic Acid / pharmacology
  • Thioctic Acid / therapeutic use*

Substances

  • Antioxidants
  • Enzyme Inhibitors
  • PrPSc Proteins
  • Thioctic Acid