Interactome networks and human disease

Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.


Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Disease / genetics*
  • Gene Regulatory Networks
  • Humans
  • Metabolic Networks and Pathways*
  • Protein Interaction Mapping
  • Proteins / metabolism*
  • Systems Biology


  • Proteins