Abstract
The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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DNA, Fungal / genetics
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DNA, Fungal / metabolism
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DNA, Ribosomal / genetics
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DNA, Ribosomal / metabolism
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Epigenesis, Genetic
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Genomic Instability
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Models, Biological
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Protein Serine-Threonine Kinases / antagonists & inhibitors
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Protein Serine-Threonine Kinases / metabolism
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / growth & development
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / antagonists & inhibitors
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Saccharomyces cerevisiae Proteins / metabolism
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Signal Transduction
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Silent Information Regulator Proteins, Saccharomyces cerevisiae / genetics
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Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism*
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Sirtuin 2 / genetics
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Sirtuin 2 / metabolism*
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Sumoylation
Substances
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DNA, Fungal
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DNA, Ribosomal
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Saccharomyces cerevisiae Proteins
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Silent Information Regulator Proteins, Saccharomyces cerevisiae
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Protein Serine-Threonine Kinases
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target of rapamycin protein, S cerevisiae
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SIR2 protein, S cerevisiae
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Sirtuin 2