Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants

J Perinatol. 2011 Dec;31(12):749-56. doi: 10.1038/jp.2011.19. Epub 2011 Mar 17.


Objective: The objective of this study is to investigate the relationship between glycemic status and severe retinopathy of prematurity (ROP).

Study design: This is a retrospective cohort study of 114 infants <1000 g admitted to a level IV neonatal intensive care unit within 48 h of life. A cumulative, time-weighted glucose level (TWGL) derived from plotting glucose values over time was included in logistic regression analysis to identify predictors for severe ROP.

Result: Infants had 26.6 ± 2 weeks gestational age and had a birth weight of 782 ± 136 g. TWGL during first 10 and 30 days of life were greater in the severe ROP group (P<0.01). Unlike single events of glucose levels ≥ 150 mg dl(-1), 10 days TWGL ≥ 100 mg dl(-1) (odds ratio (OR) 5.2, P<0.02) and 30 days TWGL ≥ 118 mg dl(-1) (OR 5.7, P<0.02) were predictors for severe ROP (univariate). Multivariate regression confirmed 30 days TWGL ≥ 118 mg dl(-1) (OR 9.4 to 10) and gram-positive sepsis (OR 4.1 to 5) as predictors for severe ROP (P<0.05).

Conclusion: High overall glycemic status is associated with the development of severe ROP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / analysis*
  • Female
  • Humans
  • Infant, Extremely Low Birth Weight*
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Retinopathy of Prematurity / blood*
  • Retinopathy of Prematurity / complications
  • Retinopathy of Prematurity / therapy


  • Blood Glucose