The influence of obesity on ICSI outcomes in women with polycystic ovary syndrome

J Obstet Gynaecol. 2011;31(3):245-9. doi: 10.3109/01443615.2010.546906.

Abstract

The objective of the study was to compare intracytoplasmic sperm injection (ICSI) outcome and gonadotropin doses between obese women with PCOS and non-obese patients with PCOS. This follow-up study represents ICSI outcomes in obese women with PCOS (BMI ≥ 30 kg/m(2)) compared with non-obese women with PCOS (BMI < 30 kg/m(2)). Obese (n = 18) and non-obese (n = 26) women with PCOS underwent long protocol pituitary suppression, ovarian stimulation and ICSI with fresh embryo transfer. Obese patients with PCOS required higher doses of gonadotropin (2994 IU vs 1719 IU; p < 0.001). Miscarriage rate was significantly higher in obese women compared with the non-obese women with PCOS (60% vs 6.7%, p = 0.002). Our results are valuable for counselling couples before initiation of assisted reproduction techniques (ART).

MeSH terms

  • Abortion, Spontaneous / epidemiology
  • Adult
  • Body Mass Index
  • Embryo Transfer
  • Female
  • Follicle Stimulating Hormone / administration & dosage
  • Humans
  • Infertility, Female / etiology
  • Infertility, Female / therapy*
  • Live Birth
  • Obesity / complications*
  • Polycystic Ovary Syndrome / complications*
  • Pregnancy
  • Recombinant Proteins / administration & dosage
  • Sperm Injections, Intracytoplasmic*
  • Treatment Outcome

Substances

  • Recombinant Proteins
  • Follicle Stimulating Hormone