Photodynamic therapy for conjunctival ocular surface squamous neoplasia

J Ocul Pharmacol Ther. 2011 Apr;27(2):205-7. doi: 10.1089/jop.2010.0113. Epub 2011 Mar 18.


Purpose: To report the case about a patient with conjunctival ocular surface squamous neoplasia who responded well to ocular photodynamic therapy (PDT).

Case: A 75-year-old man underwent PDT for his biopsy-proven conjunctival squamous cell dysplasia that was extending onto the cornea. Patient received 2 treatments of PDT with verteporfin (6 mg/m(2) body surface area, intravenously) with 2 months apart. The light dose was calculated as 50 J/cm(2). Whole lesion was irradiated 1 min after injection.

Results: Half of the mass regressed after first PDT. Second PDT resulted in near-complete cure of remaining lesion within 2 weeks. The patient remained stable for the 13 months.

Conclusion: PDT may be useful in some cases of extensive ocular surface squamous neoplasia that is less than invasive.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Carcinoma in Situ / drug therapy*
  • Carcinoma, Squamous Cell / drug therapy*
  • Conjunctival Neoplasms / drug therapy*
  • Conjunctival Neoplasms / pathology
  • Humans
  • Male
  • Photochemotherapy / methods*