Type of milk feeding affects hematological parameters and serum lipid profile in Japanese infants

Pediatr Int. 2011 Dec;53(6):807-13. doi: 10.1111/j.1442-200X.2011.03360.x.


Background: Type and volume of infant feeding determines infant growth, hematological parameters, and serum lipids.

Methods: Study subjects consisted of 103 infants who were born vaginally at term, with birthweight >2200 g. Milk feeding amount, type, and anthropometry were measured at 1 and 6 months. Hematological tests and serum lipid profile were assessed at 1 and 6 months. Thirty-four infants were breast-fed and 36 were formula-fed at 6 months.

Results: Breast-fed infants demonstrated similar growth patterns compared with partially breast-fed or formula-fed infants, despite the lower milk intake. Infants with higher breast milk intake at 6 months, however, tended to have lower hemoglobin levels. In contrast, higher formula intake at 6 months was related to lower serum total cholesterol.

Conclusions: Japanese breast-fed infants were more likely to be anemic at 6 months, while formula-fed infants were likely to have low serum lipid levels. Iron-fortified infant foods may be useful to prevent anemia in breast-fed infants. Fat quality of infant formulas should be improved to enhance lipid status of formula-fed infants.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Anemia / blood
  • Anemia / epidemiology*
  • Anemia / prevention & control
  • Animals
  • Body Weight
  • Breast Feeding*
  • Child Development / physiology*
  • Energy Intake / physiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant Food*
  • Infant, Newborn
  • Japan / epidemiology
  • Lipids / blood*
  • Male
  • Milk*
  • Prevalence
  • Retrospective Studies


  • Lipids