Autophagy: regulation by energy sensing

Curr Biol. 2011 Mar 22;21(6):R227-9. doi: 10.1016/j.cub.2011.02.007.

Abstract

Autophagy is inhibited by the mTOR signaling pathway, which is stimulated by increased amino acid levels. When cellular energy production is compromised, AMP-activated protein kinase is activated, mTOR is inhibited and autophagy is stimulated. Two recent studies have shed light on the molecular mechanism by which AMPK controls autophagic flux.

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Amino Acids / metabolism
  • Autophagy / physiology*
  • Energy Metabolism / physiology*
  • Models, Biological
  • Signal Transduction / physiology*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Amino Acids
  • TOR Serine-Threonine Kinases
  • AMP-Activated Protein Kinases