A novel pneumococcus with a new association

Travel Med Infect Dis. 2011 Mar;9(2):84-7. doi: 10.1016/j.tmaid.2011.02.005. Epub 2011 Mar 21.


A case of severe invasive pneumococcal disease in a 68 year old female is described. She presented following a holiday in Turkey with an uncommon but well documented complication of Streptococcus pneumoniae bacteraemia; Austrian's triad of meningitis, pneumonia and endocarditis. She then progressed to develop an atypical variant of Guillain Barre syndrome, never previously documented in association with pneumococcal disease. The pneumococcus was identified as serotype 6A and genetic typing by multi-locus sequence typing showed it to be a unique genetic profile (ST4533). We hypothesise that ST4533 may have resulted from genetic re-assortment from streptococci which had colonised the patient in the United Kingdom and bacteria encountered in Turkey. The ability to associate uncommon genotypes with uncommon clinical presentations may improve understanding of the pathogenesis of this organism, and this highlights the need for international invasive pneumococcal disease surveillance.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bacteremia / diagnosis
  • Bacteremia / microbiology
  • Echocardiography, Transesophageal
  • Endocarditis, Bacterial / microbiology
  • Female
  • Guillain-Barre Syndrome / complications
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / microbiology*
  • Humans
  • Meningitis, Pneumococcal / microbiology
  • Multilocus Sequence Typing
  • Pneumococcal Infections / complications
  • Pneumococcal Infections / diagnosis
  • Pneumococcal Infections / microbiology*
  • Pneumonia, Pneumococcal / microbiology
  • Scotland
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / isolation & purification*
  • Turkey