Optogenetic manipulation of neural circuitry in vivo

Curr Opin Neurobiol. 2011 Jun;21(3):433-9. doi: 10.1016/j.conb.2011.02.010. Epub 2011 Mar 21.


Recent advances in optogenetics have permitted investigations of specific cell types in the nervous system with unprecedented precision and control. This review will discuss the use of optogenetic techniques in the study of mammalian neural circuitry in vivo, as well as practical and theoretical considerations in their application.

Publication types

  • Review

MeSH terms

  • Animals
  • Genetic Techniques*
  • Humans
  • Nerve Net / physiology
  • Nervous System / cytology
  • Neurons / classification
  • Neurons / physiology*
  • Optics and Photonics / methods*