Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats

Behav Brain Res. 2011 Aug 1;221(1):329-32. doi: 10.1016/j.bbr.2011.03.033. Epub 2011 Mar 21.


Here we show that a systemic injection of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) ameliorated an aging-associated deficit in object recognition memory in rats when the injection was given immediately, but not 6h after training. NaB had no effect in younger rats with normal memory retention. The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Butyrates / administration & dosage
  • Butyrates / pharmacology
  • Butyrates / therapeutic use*
  • Histone Deacetylase Inhibitors / administration & dosage
  • Histone Deacetylase Inhibitors / pharmacology
  • Histone Deacetylase Inhibitors / therapeutic use*
  • Injections, Intraperitoneal
  • Male
  • Memory Disorders / drug therapy*
  • Rats
  • Rats, Wistar
  • Recognition, Psychology / drug effects*


  • Butyrates
  • Histone Deacetylase Inhibitors