Abstract
A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N(5)-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Arginine / metabolism*
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Gene Expression Regulation
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Ornithine / analogs & derivatives*
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Ornithine / chemical synthesis
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Ornithine / chemistry
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Ornithine / pharmacology
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Ornithine Carbamoyltransferase / antagonists & inhibitors
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Ornithine Carbamoyltransferase / metabolism
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
Substances
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Saccharomyces cerevisiae Proteins
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N(delta)-(phosphonoacetyl)-L-ornithine
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Arginine
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Ornithine
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Ornithine Carbamoyltransferase