Good response to gefitinib in a lung adenocarcinoma harboring a heterozygous complex mutation of L833V and H835L in epidermal growth factor receptor gene

J Clin Oncol. 2011 Jun 1;29(16):e468-9. doi: 10.1200/JCO.2010.33.5802. Epub 2011 Mar 21.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy*
  • Adenocarcinoma / genetics
  • Aged, 80 and over
  • Antineoplastic Agents / therapeutic use*
  • Base Sequence
  • DNA Mutational Analysis
  • ErbB Receptors / genetics*
  • Gefitinib
  • Genes, erbB-1
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Male
  • Mutation
  • Quinazolines / therapeutic use*
  • Salvage Therapy / methods

Substances

  • Antineoplastic Agents
  • Quinazolines
  • ErbB Receptors
  • Gefitinib