US vaccine refrigeration guidelines: loose links in the cold chain

Hum Vaccin. 2011 May;7(5):574-5. doi: 10.4161/hv.7.5.14489. Epub 2011 May 1.


This commentary compares Centers for Disease Control (CDC) guidelines for vaccine storage with international cold chain standards. Problems related to the use of domestic refrigerators in clinical settings are discussed. Optimal vaccine refrigerator design characteristics are summarized. The adoption of World Health Organization storage recommendations is advised.

MeSH terms

  • Centers for Disease Control and Prevention, U.S.
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
  • Diphtheria-Tetanus-acellular Pertussis Vaccines / standards*
  • Drug Storage / methods*
  • Drug Storage / standards*
  • Health Policy
  • Humans
  • Refrigeration / methods*
  • Refrigeration / standards*
  • United States


  • Diphtheria-Tetanus-acellular Pertussis Vaccines