Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure

Adv Skin Wound Care. 2011 Apr;24(4):176-81. doi: 10.1097/01.ASW.0000396302.05959.d3.


Objective: : In lower-extremity surgery, the complex wound with bone exposure remains a challenging problem for the plastic surgeon. The purpose of this study was to describe a new therapeutic approach to stimulate the regeneration of the lower-extremity complex wounds based on a combined treatment composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) dressing.

Design: : Wounds with posttraumatic bone exposure have been treated with HA dressing alone or in combination with PRP.

Patient: : Fifteen patients affected by lower-extremity wound with posttraumatic bone exposure have been treated at the Department of Plastic and Reconstructive Surgery, University of Tor Vergata, Rome, Italy.

Results: : After a single treatment, the authors observed that the mean re-epithelialization time was 8.1 weeks in 73.3% patients treated with PRP and HA dressing versus the 30% patients treated with HA dressing only.

Conclusion: : These data confirm the evidence of using PRP technology in the healing of both soft- and hard-tissue wounds. Moreover, the satisfaction of the patient confirms the quality of this study's results.

MeSH terms

  • Bandages
  • Blood Platelets*
  • Bone and Bones*
  • Feasibility Studies
  • Female
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Leg / surgery
  • Male
  • Middle Aged
  • Platelet-Rich Plasma*
  • Statistics as Topic
  • Surgery, Plastic / methods
  • Viscosupplements / therapeutic use*
  • Wound Healing
  • Wounds and Injuries / surgery*


  • Viscosupplements
  • Hyaluronic Acid