Making new out of old: recycling and modification of an ancient protein translocation system during eukaryotic evolution. Mechanistic comparison and phylogenetic analysis of ERAD, SELMA and the peroxisomal importomer

Bioessays. 2011 May;33(5):368-76. doi: 10.1002/bies.201100007. Epub 2011 Mar 21.


At first glance the three eukaryotic protein translocation machineries--the ER-associated degradation (ERAD) transport apparatus of the endoplasmic reticulum, the peroxisomal importomer and SELMA, the pre-protein translocator of complex plastids--appear quite different. However, mechanistic comparisons and phylogenetic analyses presented here suggest that all three translocation machineries share a common ancestral origin, which highlights the recycling of pre-existing components as an effective evolutionary driving force. Editor's suggested further reading in BioEssays ERAD ubiquitin ligases Abstract.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Evolution
  • Cytosol / metabolism
  • Endoplasmic Reticulum / metabolism*
  • Eukaryotic Cells / metabolism*
  • Likelihood Functions
  • Models, Biological
  • Peroxisomes / metabolism*
  • Plastids / metabolism
  • Protein Transport / physiology*