Endometrial cancer, types, prognosis, female hormones and antihormones

Climacteric. 2011 Aug;14(4):418-25. doi: 10.3109/13697137.2010.550974. Epub 2011 Mar 22.


Endometrial cancer covers several different types, the most prevalent in the developed world being endometrioid adenocarcinoma, which is estrogen-dependent and has a better prognosis compared to the non-estrogen-dependent types, e.g. papillary serous adenocarcinoma and clear cell carcinomas. Prognosis is also dependent on tumor differentiation and stage, and treatment should be adjusted accordingly. In this paper, the different types of endometrial cancer, staging, prognosis, diagnosis, prevention, treatment and their relationship to estrogen and other female hormones are reviewed.

Publication types

  • Review

MeSH terms

  • Body Mass Index
  • Contraindications
  • Endometrial Hyperplasia
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / physiopathology
  • Endometrial Neoplasms / therapy
  • Estrogen Replacement Therapy
  • Estrogens / blood
  • Female
  • Hormone Antagonists*
  • Hormones*
  • Humans
  • Middle Aged
  • Neoplasm Staging
  • Postmenopause
  • Prognosis
  • Risk Factors
  • Uterine Hemorrhage


  • Estrogens
  • Hormone Antagonists
  • Hormones