Antioxidant effect of Lagerstroemia speciosa Pers (banaba) leaf extract in streptozotocin-induced diabetic mice

Indian J Exp Biol. 2011 Feb;49(2):125-31.


Aqueous leaf extract of L. speciosa (banaba) effectively decreased the blood glucose in streptozotocin-induced diabetic mice after 15th day of banaba exposure. Further, banaba leaf extract have the potential to inhibit lipid peroxidation and effectively intercept/neutralize reactive oxygen species such as super oxide, H2O2 and NO based free radicals. The aqueous banaba leaf extract (150 mg/kg bodyweight) duly reduced STZ generated reactive intermediates and radical species helping to regulate normal levels of antioxidative markers like superoxide dismutase, catalase, glutathione-S-transferase and reduced glutathione.

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Down-Regulation / drug effects
  • Drug Evaluation, Preclinical
  • Hydrogen Peroxide / metabolism
  • Lagerstroemia*
  • Mice
  • Nitric Oxide / metabolism
  • Phytotherapy* / methods
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Streptozocin
  • Superoxides / metabolism


  • Antioxidants
  • Plant Extracts
  • Superoxides
  • Nitric Oxide
  • Streptozocin
  • Hydrogen Peroxide