Monoalkylglycerol ether lipids promote adipogenesis

J Am Chem Soc. 2011 Apr 13;133(14):5178-81. doi: 10.1021/ja111173c. Epub 2011 Mar 23.

Abstract

The molecular mechanisms that lead to the generation of adipose tissue (adipogenesis) are of basic and biomedical interest. Cellular models of adipogenesis have proven extremely valuable in defining biomolecules-primarily genes and proteins-that regulate adipogenesis. Here, the analysis of differentiating adipocytes using an untargeted metabolomics approach led to the discovery of the monoalkylglycerol ethers as a natural class of adipocyte differentiation factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • 3T3-L1 Cells
  • Adipogenesis / drug effects*
  • Animals
  • Gene Expression Regulation / drug effects
  • Glycerol / chemistry
  • Glycerol / pharmacology*
  • Lipid Metabolism / drug effects*
  • Metabolomics
  • Mice

Substances

  • Glycerol