Recurrence risk of hyperemesis gravidarum

J Midwifery Womens Health. 2011 Mar-Apr;56(2):132-6. doi: 10.1111/j.1542-2011.2010.00019.x. Epub 2011 Mar 1.


Introduction: The purpose of this study is to describe the recurrence risk for hyperemesis gravidarum (HG).

Methods: Women who registered on a Web site sponsored by the Hyperemesis Education and Research Foundation as having had one HG-complicated pregnancy were contacted to follow-up on a subsequent pregnancy. Participants completed an online survey.

Results: One hundred women responded. Fifty-seven had become pregnant again, 2 were trying to conceive, 37 were not willing to get pregnant again because of HG, and 4 did not have a second pregnancy for other reasons. Among the 57 women who responded that they had become pregnant again, 81% reported having severe nausea and vomiting in their second pregnancy. Among the women reporting recurrent HG, 98% reported losing weight and taking prescribed medication for HG, 83% reported treatment with intravenous fluids, 20% reported treatment with total parenteral nutrition or nasogastric tube feeding, and 48% reported hospitalization for HG.

Discussion: This study demonstrates both a high recurrence rate of HG and a large percentage of women who change reproductive plans because of their experiences with HG.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Hyperemesis Gravidarum / epidemiology*
  • Hyperemesis Gravidarum / prevention & control*
  • Pregnancy
  • Pregnancy Outcome
  • Registries
  • Risk Assessment*
  • Risk Factors
  • Secondary Prevention